APIREKS: Use during pregnancy and lactation

All doctors, including specialists of this site https://pillintrip.com/medicine/apireks, emphasize that any medication should be taken with extreme caution during pregnancy and breast-feeding.

Use during pregnancy and lactation: General recommendation Pregnancy Category: C / D (3 trimester.). Pregnant women / women taking contraceptives If ibuprofen is used during the first and second trimester of pregnancy, the dose for use should be low and the period of treatment should be short.

Inhibition of prostaglandin synthesis may adversely affect pregnancy and/or fetal development. Evidence from epidemiological studies has raised concerns about an increased risk of miscarriage and the development of heart defects following the use of prostaglandin synthesis inhibitors in early pregnancy.

In animals, prostaglandin synthase inhibitor use has been shown to increase pre and post-implantation loss and embryo and miscarriage.

In addition, increased incidences of various malformations, including cardiovascular malformations have been reported in animals treated with a prostaglandin synthesis inhibitor so organogenesis. Ibuprofen is not recommended during the first and second trimester unless necessary.

If ibuprofen is used during the first and second trimester of pregnancy, the dose of use should be low and the period of treatment should be short.

In the third trimester of pregnancy, all prostaglandin synthesis inhibitors may cause the following:

– Cardiac-toxicity (premature closure of the arterial duct and pulmonary hypertension);

– Renal dysfunction, which can progress to renal failure;

The mother and newborn may face the following risks at the end of pregnancy;

– Possible bleeding due to anti-aggregant effects, which can occur even at very low doses;;

– Suppression of uterine contractions, resulting in delayed or prolonged labor.

In conclusion, ibuprofen is contraindicated in the third trimester.

Breastfeeding In limited studies, ibuprofen appears in very low concentrations in breast milk and is unlikely to adversely affect breastfeeding of the baby.

Ibuprofen is also not recommended for breastfeeding mothers.

Female fertility Ibuprofen may adversely affect fertility.

It is not recommended during pregnancy.

Ibuprofen may impair female fertility through its effect on ovulation.

Discontinuation of ibuprofen treatment in women who become pregnant is required.